I have not yet played the Strat or the S1 but I got the Les Paul today and it feels in my hands like I was born to play it. The first thing I played was "Who Do You Love" in honor of the recently deceased Bo Diddley. Unfortunately, I live in a condo, so I have to listen on headphones or people start banging on the walls. It makes me wish I lived on a farm someplace where I could crank up a Marshall full stack by the barn and terrorize the chickens.
Once I finish the play I'm currently rehearsing, I hope to spend more time making music.